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The occurrence of cholangiocarcinoma has been on the rise for the past decades Cholangiocarcinoma is often anti-symptomatic until it reaches an advanced stage in its development, in which it becomes characterized by obstructive symptoms Cholangiocarcinoma is resistant to conventional forms of chemotherapy, with surgical resection being the only effective therapy We have recently shown that the enzymes [serotonin N-acetyltransferase or AANATand acetylserotonin O-methyltransferase ASMT ] regulating melatonin synthesis as well melatonin secretion are downregulated in cholangiocarcinoma lines and human biopsy samples compared to normal controls We also observed increased necrosis in sections from melatonin-treated mice compared with control mice Figure 1A,B.
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